This is something that some people deal with a lot, where after a couple of hits, they have the munches. It’s logical as well that cannabis is a natural appetite stimulant. There is research a plenty that discusses how this activates your ECS, triggering the hormones that increase hunger and also boost the food intake. The relationship however, r is a lot more nuanced and complex than that, since there are different cannabinoids which affect the appetitive in various different ways, and there is a chance that both long-term and short-term usage of cannabis does affect your hunger the energy you have, and your metabolism. 

Weed and Food: How it Affects 

Because there are a lot of Phyto cannabinoids that are similar to endocannabinoids, they do bind directly to your ECS, and it can cause major cellular changes and other cascades biochemically. Tweaking your ECS with the molecules can impact the outcome, depending on what’s used. 

THC does cause a surge in your appetite in most cases, since the cannabinoids will bind directly to your CB1 receptors as a kind of agonist, which means that the activity of the receptors are raised far above the baseline. There are various endocannabinoids that are within the body, which target this too, and it can cause dysregulation, which means that they get overactivated, which is what contributes to the sudden increase in hunger. 

CB1 is discovered to be a promising possible way to targe obesity in some people, and this also has been used as a means to target different sies in various manners.  The agonists that are inverse of CB1, such as Rimonabant, does have the opposite results that THC does, which reduces your receptor levels far below where the baseline is. 

While the drug seemed successful, it was too scattershot, and through the influence of this, it did directly mess with the mood, creating suicidal thoughts within a person. The CB2 receptors are definitely the opposite though, since if you activate those, it boosts the consumption of food. 

Cannabis and the Influence on Appetite 

This is something that a lot of people are curious about, since in  lot of cases, the munchies can feel like a super novel experience. As the research develops though, the constituents of this can cause eating disorders, obesity, and side effects of medication. 

It was something that some people are a little bit curious about, since the cannabis plant can possibly be activated. THC doesn’t create the psychoactive results because it interacts with the CB1, and the analogue of this does create an agonist along with antagonist results on the receptors. 

There are some animal studies which are looking to further  explore and go into this molecule, especially as antagonists to see how this affects weight loss, appetite, the satiety, and the upregulation of your energy, along with the metabolism of this as well. THC and CB1 is something that can possibly help with treating eating disorders too, including anorexia. While there are very few trials that have been tested on this, according to a study in 2017 that looked at the way that THC does affect the psychological results of anorexia in some of this, including self-reports of bodily care and depression. 

Plus, according to a human trial that’s randomized, they used different products and they looked at the side effects of the leptin and ghrelin increases, and how the hunger hormones were changed. Plus, there are some  side effects of chemotherapy, and also cannabis can help with some of the results that come with this, improving the caloric intake in those who need it, especially those who struggle with keeping food down.